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Thiomer Based Trans Mucosal Drug Delivery System for an Anti-Ulcer Drug- Scientific Conference 2017

Introduction: Esomeprazole magnesium trihydrate (EMT) is a proton pump inhibitor which is used for the treatment of Gastroesophageal Reflux Disease (GERD). EMT is highly unstable in the stomach and undergoes extensive hepatic

using thiolated chitosan as mucoadhesive first pass metabolism. To overcome the limitation, the present study was carried out to formulate bilayered patches of Esomeprazole for buccal delivery..

Experimental Methods: EMT containing patches were prepared by solvent casting method polymer and ethyl cellulose as the impermeable backing layer. EMT patches were evaluated for surface pH, drug content, SEM, swelling index, patch thickness, in-vitro drug release and in-vitro bioahesion studies. Accelerated stability studies were conducted.

Results: EMT containing patches showed good mucoadhesive strength in the range of 74 - 115g. In-vitro drug release studies showed that the formulations with high ratios of the polymers were able to sustain the drug release up to 8 h.

Conclusions: The results of in-vitro drug permeation studies suggested that as the concentration of the polymer increased, the drug permeation increased. Formulation containing the highest ratio of thiolated Chitosan was found to be the best formulation in terms of mucoadhesive strength, drug release and permeation. The accelerated stability studies revealed drug that there was no significant difference in the patches after a period of 6 months. Thus a stable, safe and effective bilayered mucoadhesive delivery system of Esomeprazole in the form of patches was prepared to improve drug bioavailability, avoid degradation of the drug and also to prevent drug loss in saliva.

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World Congress on Genetics,
Genomics and Personalized Medicine 2017
Biogenesis Health Cluster.

M: +91 9886327807, RSVP: Ms. Radhika
info@geneticsgenomicsmedicine.com